The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress

https://pmc.ncbi.nlm.nih.gov/articles/PMC4684895/

Hugo Juárez Olguín, David Calderón Guzmán, Ernestina Hernández García, Gerardo Barragán Mejía

First published: 06 December 2015

https://doi.org/10.1155/2016/9730467

Citations: 267

Academic Editor: Anne-Laure Bulteau

This article is part of Special Issue:

Neurodegeneration, Neurogenesis, and Oxidative Stress 2015
 

The article "The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress" by Juárez Olguín et al. (2016) explores how oxidative stress—an imbalance between free radicals and antioxidants—impacts dopamine (DA) systems in the brain. Dopamine is crucial for regulating mood, motivation, motor control, and reward.

This comprehensive review underscores the importance of maintaining oxidative balance to preserve dopamine system integrity and prevent related neurological disorders.

Key Points:

* Oxidative Stress and Dopamine Dysfunction: The authors discuss how oxidative stress can damage dopaminergic neurons, leading to impaired dopamine synthesis, release, and receptor function.

* Neurodegenerative Diseases: The review highlights the role of oxidative stress-induced dopamine dysfunction in the pathophysiology of neurodegenerative diseases such as Parkinson’s disease and schizophrenia.

* Therapeutic Implications: The article suggests that targeting oxidative stress pathways could offer potential therapeutic strategies for conditions associated with dopaminergic dysfunction.

* This comprehensive review underscores the importance of maintaining oxidative balance to preserve dopamine system integrity and prevent related neurological disorders.

Implications for Human Health and Society:

• Insight into disease mechanisms: Helps understand the root causes of brain disorders.
• Therapeutic direction: Supports the development of antioxidant-based treatments.
• Preventive strategies: Encourages lifestyle changes to reduce oxidative stress.